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Clinical trials to assess adjuvant therapeutics for severe malaria

The current model for assessing adjunctive therapies for severe malaria (i.e. randomized controlled trials) is limited by the large number of participants required to reach mortality endpoints. This barrier requires innovative solutions including the use of surrogate markers of mortality. In this opinion piece, we examine the use of immune and endothelial activation markers involved in the pathobiology of severe malaria, as potential surrogate markers of mortality. In addition, we highlight the importance of risk-stratifying participants with these same biomarkers and the potential of repurposing drugs active on those pathways to accelerate the identification of effective adjunctive therapeutics.

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Authors: Daniele Rocha, Gisely Cardoso de Melo, José Marcelo Hipólito Carneiro, Marisa Ribeiro, Sthefanie Ribeiro, Daniela Tupy de Godoy, Anne Cristine Gomes de Almeida, Elisabete Ferreira de Andrade, Cláudia Maria de Moura Abrahim, Nelson Abrahim Fraiji, Antonio Gomes Pinto Ferreira, Wuelton Marcelo Monteiro, Rodrigo Brindeiro, Amilcar Tanuri, Marcus Vinicius Guimarães de Lacerda and Patrícia Alvarez

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31 July 2023
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免费富强软件Manas Kotepui, Kwuntida Uthaisar Kotepui, Giovanni D. Milanez and Frederick R. Masangkay

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31 July 2023
Measuring ventilation in different typologies of rural Gambian houses: a pilot experimental study

Authors: Jakob B. Knudsen, Margaret Pinder, Ebrima Jatta, Musa Jawara, Mahamed A. Yousuf, Amalie T. Søndergaard and Steve W. Lindsay

Content type: Research

31 July 2023
“After those nets are torn, most people use them for other purposes”: an examination of alternative bed net use in western Kenya

Authors: Ellen M. Santos, Jenna E. Coalson, Stephen Munga, Maurice Agawo, Elizabeth T. Jacobs, Yann C. Klimentidis, Mary H. Hayden and Kacey C. Ernst

Content type: Research

29 July 2023
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Authors: Lawrence S. Redmond, Martin D. Ogwang, Patrick Kerchan, Steven J. Reynolds, Constance N. Tenge, Pamela A. Were, Robert T. Kuremu, Nestory Masalu, Esther Kawira, Isaac Otim, Ismail D. Legason, Herry Dhudha, Leona W. Ayers, Kishor Bhatia, James J. Goedert and Sam M. Mbulaiteye

Content type: Research

28 July 2023

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Authors: Jane Achan, Ambrose O Talisuna, Annette Erhart, Adoke Yeka, James K Tibenderana, Frederick N Baliraine, Philip J Rosenthal and Umberto D'Alessandro

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24 May 2011
Plant-based insect repellents: a review of their efficacy, development and testing

Authors: Marta Ferreira Maia and Sarah J Moore

Content type: Reviews

15 March 2011
Use of antenatal care, maternity services, intermittent presumptive treatment and insecticide treated bed nets by pregnant women in Luwero district, Uganda

Authors: Mpungu S Kiwuwa and Patrobas Mufubenga

Content type: Research

1 March 2008
Malaria in infants aged less than six months - is it an area of unmet medical need?

Authors: Umberto D’Alessandro, David Ubben, Kamal Hamed, Serign Jawo Ceesay, Joseph Okebe, Makie Taal, Eugene Kaman Lama, Moussa Keita, Lamine Koivogui, Alain Nahum, Kalifa Bojang, Aja Adam Jagne Sonko, Honorat Francis Lalya and Bernard Brabin

Content type: Opinion

2 December 2012
Paracheck-Pf^® accuracy and recently treated Plasmodium falciparum infections: is there a risk of over-diagnosis?

富强上网appTodd D Swarthout, Helen Counihan, Raphael Kabangwa K Senga and Ingrid van den Broek

Content type: Research

16 May 2007

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Parasite and vector papers during the COVID-19 publication rush

05 June 2023
Humans: are we the most effective vector of disease?

01 May 2023
Malaria during the COVID-19 pandemic

17 April 2023

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As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times. Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.

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Alternative interventions to facilitate malaria elimination
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Malaria Journal, in partnership with Research Square, is offering In Review. Authors choosing this free optional service will be able to:

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Malaria Journal is aimed at the scientific community interested in malaria in its broadest sense. It is the only journal that publishes exclusively articles on malaria and, as such, it aims to bring together knowledge from the different specialties involved in this very broad discipline, from the bench to the bedside and to the field.

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